Poisoning and Biogenic Amines - the cause of
This theory proposes that ME arises from the poisoning of
those enzymes in the body that breakdown neurotransmitter-like substances called
The resulting build up of biogenic amines causes many of the
symptoms of ME, from dysfunction in the energy producing mitochondria of cells,
to gut and neurological problems.
The biogenic amines also allow micro-organisms to
flourish in the
previously less colonised upper parts of the gastrointestinal (GI) tract. These micro-organisms themselves produce biogenic
amines. Thus a vicious circle is set up enabling the development of persistent
(chronic) ME. Anything that leads to micro-organism overgrowth in the upper GI
eg. a virus infection or stress - can trigger a sudden onset or relapse.
One poison source is suspected to be indoor air pollution -
possibly the combination of formaldehyde and ammonia gases. Measures to
significantly increase fresh air exposure of patients may thus be
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